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Home »Detabase » Lactabase » Beta Lactamase » Beta Lactam Antibiotics » Penicillin » Extended-spectrum

Extended-spectrum

Extended-Spectrum Penicillin are also known as aminopenicillin

Example:

Azlocillin:

Azlocillin is an acylampicillin antibiotic with an extended spectrum of activity and greater in vitro potency than the carboxy penicillins. Azlocillin is similar to mezlocillin and piperacillin. It demonstrates antibacterial activity against a broad spectrum of bacteria, including Pseudomonas aeruginosa and, in contrast to most cephalosporins, exhibits activity against enterococci.

Azlocillin

Fig: Azlocillin

Carbenicillin:

Carbenicillin is a bactericidal and bacteriolytic antibiotic belonging to the carboxypenicillin subgroup of the penicillins. It has gram-negative coverage which includes Pseudomonas aeruginosa but limited gram-positive coverage. The carboxypenicillins are susceptible to degradation by beta-lactamase enzymes, although they are more resistant than ampicillin to degradation. Carbenicillin is also more stable at lower pH than ampicillin.

The antibiotic is very soluble in water and is acid-labile. Aqueous solutions are short-lived. Working concentration in the lab: up to 100 µg per ml.

It is a semi-synthetic analogue of the naturally occurring penicillin.

In molecular biology, Carbenicillin may be preferred as a selecting agent because its breakdown results in byproducts with a lower toxicity to analogous antibiotics like ampicillin. However, in most situations this is not a significant problem so ampicillin is used due to its lower cost.

Carbenicillin

Fig: Carbenicillin

Ticarcillin:

Ticarcillin is a carboxypenicillin. It is almost invariably sold and used in combination with clavulanate as Timentin. Because it is a penicillin, it also falls within the larger class of beta-lactam antibiotics. Its main clinical use is as an injectable antibiotic for the treatment of gram-negative bacteria, in particular, Pseudomonas aeruginosa.

It is provided as a white or pale-yellow powder. It is highly soluble in water, but should be dissolved only immediately before use to prevent degradation.

Ticarcillin

Fig: Ticarcillin