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Serine Beta Lactamse

The Serine β-lactamases use an active site serine to catalyze the hydrolysis of the β-lactam bond in β-lactam antibiotics. They fall into three families: Class A, which includes three widely distributed TEM and SHV β-lactamases, Class C, also known as the AmpC ß-lactamases, and Class D, also known as the Oxa β-lactamases.

At the amino acid sequence level there is homology within each class, but no detectable homology between classes. At the structural level there is homology among the classes.

Select the menu under the Bioinformatics software menu on the top of the page to access the pages for the Serine Structural Phylogeny, the Class A phylogenies, the Class C phylogenies and the Class D phylogeny